Matt Renshaw potentially could replace Warner for the final Test in Johannesburg.
Queensland opener Matt Renshaw is set to fly to South Africa immediately after the conclusion of the Sheffield Shield final in Brisbane, which ends today.
Australian squad have been hit hard by the ball-tampering incident which took place during third Test match.
Renshaw, who was dropped for the 2017-18 Ashes at home last summer, has shown tremendous form since the Shield resumed post the Christmas break.
The investigation pertaining to the ball tampering scandal kicked off on Monday as some of the players and support staff were interviewed by Cricket Australia officials.
Smith has been banned for one Test by the International Cricket Council for his role in a plot that saw team-mate Cameron Bancroft tamper with the ball by using yellow sticky tape during the third Test against South Africa in Newlands.More news: Investigators search Cambridge Analytica's London offices
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Renshaw was dropped for the Ashes, but got the call to return to the worldwide stage on Tuesday amid a ball-tampering scandal which has shamed the tourists.
South Africa lead the series 2-1.
"It's pretty surreal", Renshaw said.
While Bancroft only averaged 25.57 with the bat during the Ashes, he has fared a little better in the ongoing Test series against the Proteas as he is Australia's highest run-scorer with 223 runs, which includes two half-centuries, at an average of 37.16.
Other players were expected to join Renshaw on flights to South Africa, with reports fellow Queensland and former test opener Joe Burns is among those in the mix for selection.
Previous Shield-winning Queensland captains include Allan Border, Jimmy Maher, Stuart Law and James Hopes, with Peirson now joining them having just 16 first class games to his name.
Before the proceedings started, the players talked to Australian Cricketers' Association chief executive Alister Nicholson.