Mourinho and Wenger have clashed over the years, with the former famously describing the latter as "a specialist in failure" in 2014, but the Arsenal boss says their relationship is more positive than people might expect.
Wenger's men have lost 13, won 2 and drawn 3 of their last 18 away visits to Old Trafford.
In that context, Sunday's farewell on which nothing rests promises to be a low-key affair with Arsenal set to field a weakened team ahead of next week's Europa League semi-final second leg against Atletico Madrid.
Ferguson announced he was quitting in 2001 and would be done at the end of the season, and so United began talking to potential replacements for the fiery Scot.More news: Comcast formally takes on Murdoch with pound sterling22bn Sky bid
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"Man United fans know that until 2004 for about a decade was between Man United and Arsenal, was between Sir Alex and Mr Wenger and I think that these great teams Arsenal had made Man United better and better". Goalkeeper Sergio Romero however, is out with a knee problem.
In terms of injuries, the Gunner will still miss out on Cazorla and Mohamed Eleny.
Much will depend on what sort of lineup Wenger names; a decision that could shape this game.
Sanchez could indeed be the "X" factor this weekend, and it will be interest to note what sort of reaction he gives should he find the net.
The outgoing Arsenal boss now takes home £8 million-per-year - exactly half of what Manchester City pay the leading Premier League earner Pep Guardiola.
Old Trafford has not been a happy hunting ground for the Frenchman since taking charge of the north London club 22 years ago, but he has certainly had his fair share of triumphs in the north-west of England.