One dead, three injured in explosion at California medical center

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At least one person was killed and three others injured after an explosion at a two-story medical office building in Southern California, fire officials confirmed Tuesday afternoon. Investigators believe the blast may have come from a package, according to an official who was briefed on the investigation but wasn't authorized to discuss the matter publicly and spoke to the Associated Press on condition of anonymity.

Tony Bommarito of the Orange County Fire Authority said, according to NBC News.

Federal Bureau of Investigation spokesman Mike Gifford had said earlier there was no initial indication of terrorism in the facility about 7 miles northeast of Laguna Beach.

A daycare and preschool are near the site of the explosion, but authorities said all of the children are safe.

"We have not determined what caused the blast", said Carrie Braun, a Public Information Officer at Orange County Sheriff's Department.

Mary McWilliams told the Orange County Register she arrived for an appointment to find smoke surrounding the area and vehicle alarms going off. OCFA said a bomb squad was sent in to assess the situation and investigate the cause of the blast.

McWilliams says she saw two women covered in ash and soot stagger out of the building.

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The powerful blast blew out almost the entire bottom floor, officials said.

They said they were not actively looking for any suspects.

Children at a day care across the street from the building were evacuated.

Dong Shin said he had seen "fire, smoke, insulation popping out of the walls, a lot of scared people running around, a lot of commotion".

There were unconfirmed initial witness reports that the blast may have been a gas explosion, but Bommarito said it is rare for such gas-fueled blast to occur in a commercial building. They expected a lengthy investigation to determine the cause.

Little children holding hands and others being pushed in rolling cribs were led by firefighters to a Target parking lot to be united with parents.