Video images published by Sacatepezuez television showed a charred landscape where a lava flow came into contact with homes.
At least 20 people were injured, and authorities have said they feared the death toll could rise with an undetermined number of people unaccounted for.
The worldwide airport in Guatemala City - around 27 miles away - was forced to close, after the runway and aircrafts were covered with volcanic materials.
Other videos from local media showed residents walking barefoot and covered in muddy residue.
The Israeli government said Monday it was sending emergency aid worth $10,000 (€8,560) to Guatemala.
"It's a river of lava that overflowed its banks and affected the El Rodeo village".
One woman told the Diario de Centroamerica that lava had poured through corn fields and she thought more people may have died.
An ambulance of the volunteer firefighter unit carries the wounded from the village of El Porvenir after the eruption.
Among the fatalities were four people, including a disaster agency official, killed when lava set a house on fire in El Rodeo village, Cabanas said.More news: Assassin's Creed: Odyssey teaser suggests ancient Greek setting
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"Not everyone escaped, I think they were buried", Consuelo Hernandez said. "There are injured, burned and dead people", Cabanas said on radio.
Dozens of people are missing with over 2,000 more having been evacuated from the affected areas, the Noticias 4Vision broadcaster reported.
The eruption on June 3 was the second of the year and most powerful eruption since 1974.
A disaster authority spokesman said a change in wind direction was to blame for the volcanic ash falling on parts of the capital.
It urged residents living near the volcano to evacuate immediately and warned residents of the towns of Chimaltenango, Sacatepequez and Escuintla to watch out for volcanic rocks and ash. Numerous dead came from the three towns of El Rodeo, Alotenago and San Miguel los Lotes.
It is near the colonial city of Antigua.
Aviation authorities there closed the worldwide airport due to the potential danger to planes by the ash, the AP reported.
The volcano's peak soars 3,763 meters (12,346 feet) above sea level.