Smolnikov tried to make his mark on Uruguay with crunching tackles, but that just brought two yellow cards and a sending-off in the 36th minute.
Uruguay go into the game having yet to concede a goal at Russian Federation 2018, seeing off Egypt and Saudi Arabia both by 1-0 scorelines.
Follow live updates from Group A as Russian Federation take on Uruguay. The Paris Saint-Germain forward put a rebound into the left corner of the net after Diego Godin's header was parried by Akinfeev. Gimenez scored in the team's opening match of the tournament, a 1-0 victory over Egypt.
It was Suarez's second goal of the tournament and seventh World Cup goal overall for Uruguay, with only Oscar Miguez having scored more for the South Americans with eight.
23' GOAL! Uruguay 2-0 Russia: Uruguay have scored a second!
"The only plus is that we'll play at Luzhniki", Cherchesov said.
The 6-1 win over Panama - England's largest-ever margin of victory at the World Cup - was watched by 14.1 million, which was nearly 83 percent of the TV audience in Britain.More news: England fans flock to Russian Federation for group decider against Belgium
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Uruguay would have had a third soon after if not for a fine save from Akinfeev, who prevented Bentancur celebrating his 21st birthday with a goal.
In the other match of this group of Saudi Arabia for the first time since 1994 won the world Cup. "I like how my team played after we lost one player".
Speaking after the game, and quoted by Russia Today, Cherchesov acknowledged that the Uruguayans were far superior to the Russians' previous World Cup opponents, Saudi Arabia and Egypt. "Uruguay is a team on another level", he said, explaining: "Today the speed was different and the characteristics of the opponent were different".
Salem Aldawsari scored with nearly the last kick, shooting from a tight angle inside the Egypt penalty area and poking the ball past El Hadary.
A 1-0 defeat of Egypt was mirrored against Saudi Arabia but Tabarez's side undoubtedly have more to prove in their last group game. The decision was confirmed after a video review.
There was plenty of noise from the stands - so Uruguay goalkeeper Fernando Muslera will have had many quieter games in terms of volume - but he had little work to do as he became his country's all-time leading appearance maker at the World Cup.
At the opposite end of the pitch, Suarez provided that extra touch of quality that Saudi Arabia - or a half-fit Mohamed Salah - could not.
Russia, meanwhile, will face Group B winners Spain after last night's 2-2 draw with Morocco.