In Godin and Jose Gimenez, Uruguay have one of the most priceless commodities in global football - a centre-back pairing which plays together week in and week out for Atletico Madrid.
Since Uruguay and Portugal have not faced each other since a friendly match in 1972, Cristiano Ronaldo hasn't had the chance to take on Suarez and Cavani together, but he has done it separately and scored more than both.
There has been little love lost when they have met: Ronaldo once punched Godin during a Spanish Super Cup tie, but the defender got his own back in a meeting past year by elbowing the Portuguese in the head.
"We will mark him with the same respect we mark everyone, despite him being a superstar", said Sebastian Coates of Ronaldo.
Uruguay won all three of their group matches, beating hosts Russian Federation 3-0 in their last outing, and are the only team yet to concede a goal at the tournament.
"But what he has on top of all those qualities, he's the leader of that team, and there is not one single player who can contain him. We have our weapons and we're going to try to win". "If Ronaldo plays alone we will lose", said Santos, whose team have gone 17 games without losing - not including penalty shoot-outs - at an global tournament.
Uruguay's formidable defence have not let in a goal at all in 2018, while Suarez has recovered from a poor first outing in Russian Federation to score in wins over Saudi Arabia and the hosts.More news: Zimbabwe To Hold July Elections Despite Rally Attack
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Luis Suarez and Edinson Cavani looked razor sharp in training as Uruguay fine-tuned their preparations ahead of the World Cup last 16. While same goes for the Portuguese players and their immediate nemesis, Luis Suarez.
Santos played down suggestions that fans might be in for a boring game as two teams with water-tight defences face off.
That, and Portugal's recent track record of being involved in tense knockout matches that have gone to the wire, has raised the prospect of a nail-biting contest as the World Cup heads into its latter stages.
I expect a tough and very physical match with a penalty shootout to determining the winners of this match. They were poor against Iran and I think this is where their tournament ends.
Penalty shoot-outs excluded, Portugal have lost only one of their last 17 games at major tournaments (won eight, draw eight), a 4-0 defeat against Germany at the 2014 World Cup.
"I think we are closer than ever to it".