Suarez and Cavani have both found the net in three consecutive World Cups, and they have five goals between them here in Russian Federation.
The teams will face off at 2 p.m. ET on Saturday in Sochi, Russia, in the 2018 World Cup Round of 16.
Ronaldo helps the injured Cavani from the field.
Portugal hasn't reached the World Cup quarterfinals since 2006, when a young Ronaldo led the team to the semifinals.
The loss for Portugal against Uruguay ended the dream of legendary Cristiano Ronaldo, who alongside Argentina's Lionel Messi, may have to end a stellar worldwide career without the biggest trophy in football.
From it, Portugal were level as Pepe stormed in to head home from Guerreiro's delivery and grab the goal that they had increasingly threatened since the break.More news: Germany v South Korea
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That was the first goal the twice World Cup champions had conceded in the tournament in Russian Federation, but another moment of brilliance from Cavani put them back ahead seven minutes later at the packed Fisht Stadium overlooking the Black Sea. Ronaldo started off this year's tournament with a hat trick against Spain and then added another goal against Morocco.
When the former Manchester United player had flat game In Portugal's final group stage outing against Iran, Ricardo Quaresma chipped in with a goal to see Porgual over the line, and might have again, had his extra time effort not been fired straight into the waiting hands of Muslera.
Uruguay played a flawless group stage against relatively weak opponents to make it to the Round of 16, but the South American side proved it has what it takes to make a deep run at the World Cup by sending the reigning European champions home on Saturday.
"We must congratulate Uruguay because they are the national team that are in the quarter-finals", he said in his post-match interview.
"In football, there are no moral victories and I would have preferred to play worse and win the match", Portugal coach Fernando Santos said.
But Santos said he still hopes to see the 33-year-old add to his 154 caps and 85 global goals. Forging a simply unstoppable partnership with Suarez, Uruguay look like scoring every time they come forward.