Chelsea have won their first four games under Sarri and Luiz has played in all of them.
Chelsea will host to Cardiff City and Luiz will be looking to help his side keep a clean sheet and maintain their 100 per cent record.
Sarri spent the September global break in England, dividing his time between walking his dog Ciro around the large garden of his new house a short drive from Chelsea's training ground in Surrey - "Similar to my name", he joked - and studying video of his team's upcoming opponents.
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When asked about who are the contenders for the trophy this term, he said: "At the moment, I can answer City or Liverpool".
But in the last 12 meetings, Chelsea won 10, including both previous Premier League encounters in the 2013-14 season.
"I don't know now the situation". I think it is right that he tries to play. "[But] in this first period, for me, it was very important not to change, especially the defensive line".
"I am very open with him, because he's the history of the club".
But the timing of the fixture makes a damaging setback more likely according to Sarri, who said that he encountered a similar problem during his time in charge of Napoli. "I am trying", Sarri said. I feel like at home. But, for me, it's a pleasure.
"I hope in the future I will be able to give him space, to give space to [Callum Hudson] Odoi and [Ruben] Loftus-Cheek. It's 12 or 13 hours, but for me it's not working".