Moreover, Messi already made a hat-trick in his first Champions League game with PSV.
'He set the standard, he and Cristiano Ronaldo gone above the normal standard, when they are scoring 50 or 60 goals a season, ' said Kane.
"As a striker I want to try and match that".
"He's definitely set the standard for the rest of us".
Messi has reportedly responded to Pique by criticizing Barcelona's defence, stating that the side has conceded way too many goals and that the defence needs to do more work.
The quintet will also not be fit for the Premier League match with struggling Cardiff on Saturday.
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And to achieve that goal, they will need England captain Kane at his lethal best.
"We don't want to start with two defeats and we know that Barcelona is a big challenge, but in our stadium we must be strong and look forward".
Kane and co can also draw on the memories of last season's stunning 3-1 Wembley win over Real Madrid. It was not so great to lose to Inter this time around, ' added Kane.
"It's a very important match, they're a fantastic opponent, but we've shown in recent years that we can beat top teams", he continued. What we need is to have players helping each other. "It is a period when we are not in good luck with injuries..."
Barcelona coach, Ernesto Valverde will be without defender, Sergi Roberto, who sustained an injury against Athletic, while Samuel Umtiti is both injured and suspended.
Serge Aurier, Mousa Dembele, Christian Eriksen and Jan Vertonghen will join Dele Alli in missing Tottenham's Champions League clash with Barcelona - but Hugo Lloris will start on Wednesday.