He was suffering from age-related illness for the past few years and was admitted to the hospital due to an attack of pneumonia. Way back in 1961, after working his way up from an assistant, Lee co-founded Marvel Comics with his co-creator, Jack Kirby.
However, Avengers 4 co-director Joe Russo confirmed that Lee already shot his cameo in the film in an interview with BBC Scotland: "He doesn't love to fly, so typically we try to get him out for his cameos around the same time".
The 32-year-old actor took to Twitter to criticise celebrities posted pictures of themselves with the legendary icon.
Shortly afterwards, "Stan Lee's Lucky Man" debuted overseas.
"Stan Lee was as extraordinary as the characters he created".
Kevin Feige and Joss Whedon, both hugely instrumental in shaping the MCU in their own way, have also shared the tremendous impact Stan Lee had on the pair of them.
The legend created several comics adored today, including Spider-Man, the X-Men, Black Panther, The Fantastic Four, Iron Man and The Avengers. The group is cooperating with KBS Hallyu Investment Partners to create the first Korean drama adapted on Stan Lee IP, and is developing an oriental superhero movie in cooperation with Linking Star Pictures.More news: Schmidt a good All Blacks fit, says McCaw
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"I chose Superman because I think not only the people of Marvel and the followers are sad about it, but everyone, including those who prefer DC comics", he told the Press Association.
Marvel posted numerous tributes on its website.
Lee's birth name was "Stanley Martin Lieber", but used "Stan Lee" as his pen name and then later had it legally changed.
In a statement the Walt Disney Company, which bought Marvel Entertainment in 2009, saluted Lee's "unmatchable" life and career.
Foster, who started reading Marvel Comics in the 1960s, said even doing something as minor as including people of colour in the background was monumental.
"There will never be another Stan Lee".