Metro areas that are included in warnings are Kansas City, St. Louis, Indianapolis, Cincinnati, Washington D.C., Roanoke and Greensboro - these areas are most likely to see risky travel conditions and heavy snow and/or ice according to The Weather Channel.
Washington and Baltimore will likely see 2 to 4 inches of snow and Philadelphia 1 to 2 inches.
Parts of the Mid-Atlantic are bracing for the first major snow storm of the new year. Gia has most of the midwest in a winter storm warning, with anticipated snowfall ranging from 3 inches to more than a foot.
Casualties included a woman and her 14-year-old stepdaughter whose auto slid into the path of a semitrailer in Clinton, about 80 miles southeast of Kansas City, on January 11, the Missouri State Highway Patrol said.
Virginia State Police said the driver of a military surplus vehicle was killed late Saturday after he lost control on Interstate 81 because of slick road conditions.
Drivers weren't the only ones negatively affected by the extreme weather conditions: Dozens of flights were cancelled at St. Louis Lambert International Airport, which described the snowstorm as one of the largest on record.
Jacksonville, some 30 miles (50 kilometers) west of Springfield, got even more at almost 16 inches (40 centimeters). In Columbia, 15.5 inches were reported and Harrisburg had 17 inches.
Weather map of the National Weather Service shows the snowstorm moved into Kansas and Nebraska from the Rockies on Friday then went eastward into Missouri, Iowa, Illinois, and Indiana. The state police said earlier that they have responded to more than 200 snow-related crashes, including one other fatality.More news: Aaron Ramsey and Juventus agree terms on free transfer
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It is forecast to leave up to 10 inches (25cm) of snow in Washington DC and parts of Maryland by Sunday and there could also be heavy snow in Virginia.
The Appalachians will pick up some snow and sleet in Virginia, down through North Carolina and Tennessee.
Springfield's State Journal-Register reports that the state capital broke a 55-year record for daily snowfall on Saturday.
On Saturday, Kansas and Missouri officials took to social media to ask residents to watch the weekend's football attraction - the Kansas City Chiefs hosting the Indianapolis Colts - from home.
An American flag waves in front of the US Capitol Dome as a winter storm arrives in the region on Sunday. Auto accidents resulting from icy, snow-covered roads were already being reported on Saturday evening.
North Carolina Gov. Roy Cooper has declared a state of emergency that he says will help utility crews restore electricity more quickly to the state's western Piedmont, foothills and mountains after a winter storm.
More than 450 flights across the USA had been canceled on Sunday morning, according to Flight Aware.