The drugs were hidden in metal boxes and falsely labelled as loudspeakers.
In addition to the 3,810 pounds of meth, the shipment also contained 55.9 pounds of cocaine and 11.5 pounds of heroin.
The drugs were seized at the Los Angeles/Long Beach seaport on January 11.
"There's no question that the criminal organization behind this scheme has been dealt a significant blow", Joseph Macias, special agent-in-charge for Homeland Security Investigations (HSI) Los Angeles, said in a statement.
Four people have been arrested in Victoria including an American man and woman, while two others have been arrested in New South Wales.
AFP organised crime assistant commissioner Bruce Hill said Australia had been a target of the Mexican cartels for years, because of the high prices drugs command.More news: Pope Francis arrives to hold public mass in UAE
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Australian police have arrested six people in Victoria and New South Wales after the biggest seizure of crystal methamphetamine in U.S. history. They've been sending smaller amounts over the years.
"If this shipment had made Australian streets it equates to something like 17 million hits of ice".
"This is the biggest ever seizure of methamphetamine. stopped before it had a chance to reach Australian streets", said AFP Asst. Help us celebrate and post your best ice puns below. Police said the raid in the Melbourne suburb of Woodstock in which they were arrested also found "hundreds of thousands of dollars of proceeds of crime".
The Echo Task Force then continued to investigate the drug possession, and following this, police began to investigate the possible involvement of Australian gangs, which lead police to the discovery of the drugs and the arrests.
"The cartel is one of the most powerful and violent drug trafficking syndicates in the world", he said, without naming the cartel involved.
Three of those arrested, including the American couple, were due to appear in a Melbourne court Friday on a charge of attempting to import controlled drugs.